Effect of short periods of normobaric hyperoxia on local brain tissue oxygenation and cerebrospinal fluid oxidative stress markers in severe traumatic brain injury.

@article{Puccio2009EffectOS,
  title={Effect of short periods of normobaric hyperoxia on local brain tissue oxygenation and cerebrospinal fluid oxidative stress markers in severe traumatic brain injury.},
  author={Ava M. Puccio and Leslie A Hoffman and H{\"u}lya A Bayir and Thomas G. Zullo and Michael C. Fischer and Joseph M. Darby and Sheila Alexander and C Edward Dixon and David O. Okonkwo and Patrick M Kochanek},
  journal={Journal of neurotrauma},
  year={2009},
  volume={26 8},
  pages={1241-9}
}
Preliminary evidence suggests local brain tissue oxygenation (PbtO(2)) values of <or=15 mm Hg following severe traumatic brain injury (TBI) represent brain tissue hypoxia. Accordingly, many neurotrauma units attempt to maintain PbtO(2) >or=20 mm Hg to avoid hypoxia. This study tested the impact of a short (2 h) trial of normobaric hyperoxia on measures of oxidative stress. We hypothesized this treatment would positively affect cerebral oxygenation but negatively affect the cellular environment… CONTINUE READING

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