Effect of shear stress on the hydraulic conductivity of cultured bovine retinal microvascular endothelial cell monolayers.

@article{Lakshminarayanan2000EffectOS,
  title={Effect of shear stress on the hydraulic conductivity of cultured bovine retinal microvascular endothelial cell monolayers.},
  author={Srinivasa Lakshminarayanan and Thomas W. Gardner and John M. Tarbell},
  journal={Current eye research},
  year={2000},
  volume={21 6},
  pages={
          944-51
        }
}
The shear stress of flowing blood on endothelial cells increases water transport (hydraulic conductivity, Lp) in several vascular beds in vivo and has been hypothesized to play a role in elevating vascular transport in ocular diseases such as diabetic retinopathy. The purpose of this study is to determine the response of Lp to varying levels of shear stress using an in vitro model of the blood-retinal barrier: bovine retinal endothelial cells (BRECs) grown on polycarbonate filters. The study… CONTINUE READING
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