Effect of shRNA targeting survivin on ovarian cancer

@article{Xing2012EffectOS,
  title={Effect of shRNA targeting survivin on ovarian cancer},
  author={Jun Xing and Chang-ru Jia and Yanli Wang and Jing Guo and Yan Cai},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2012},
  volume={138},
  pages={1221-1229}
}
This study investigated the effect of shRNA targeting survivin on cultured ovarian cancer cells and on a murine ovarian cancer xenograft. An RNAi plasmid for survivin was transfected into SKOV3 cells, and the effect of shRNA targeting survivin on the expression of survivin was determined. Transmission electron microscopy (TEM), flow cytometry, and TUNEL staining were used to assess apoptosis. The MTT assay was used to measure cell growth and changes in cisplatin sensitivity. SKOV3 cells were… CONTINUE READING

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