Effect of serotonin on Y-maze retention and hippocampal protein synthesis in rats.

@article{Wetzel1980EffectOS,
  title={Effect of serotonin on Y-maze retention and hippocampal protein synthesis in rats.},
  author={Wolfram Wetzel and V. M. Getsova and Reinhard Jork and Hansj{\"u}rgen Matthies},
  journal={Pharmacology, biochemistry, and behavior},
  year={1980},
  volume={12 2},
  pages={319-22}
}
The effect of serotonin (5-HT) on consolidation of a brightness discrimination reaction was investigated in rats. Five microgram 5-HT, injected intrahippocampally immediately after training, impaired retention of the brightness discrimination tested 24 hr later. In biochemical experiments, leucine incorporation into hippocampal proteins in vivo was 32% inhibited by 5 microgram 5-HT. Leucine incorporation into proteins of hippocampal slices in vitro was decreased by 5 x 10(-5)M 5-HT. The results… CONTINUE READING

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