Effect of sequence variation in Plasmodium falciparum histidine- rich protein 2 on binding of specific monoclonal antibodies: Implications for rapid diagnostic tests for malaria.

@article{Lee2006EffectOS,
  title={Effect of sequence variation in Plasmodium falciparum histidine- rich protein 2 on binding of specific monoclonal antibodies: Implications for rapid diagnostic tests for malaria.},
  author={Nelson Lee and Joanne Baker and Kathy T Andrews and Michelle L. Gatton and David Bell and Qin Cheng and James S McCarthy},
  journal={Journal of clinical microbiology},
  year={2006},
  volume={44 8},
  pages={2773-8}
}
The ability to accurately diagnose malaria infections, particularly in settings where laboratory facilities are not well developed, is of key importance in the control of this disease. Rapid diagnostic tests (RDTs) offer great potential to address this need. Reports of significant variation in the field performance of RDTs based on the detection of Plasmodium falciparum histidine-rich protein 2 (HRP2) (PfHRP2) and of significant sequence polymorphism in PfHRP2 led us to evaluate the binding of… CONTINUE READING

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