Effect of selenium supplementation in hypothyroid subjects of an iodine and selenium deficient area: the possible danger of indiscriminate supplementation of iodine-deficient subjects with selenium.

Abstract

Selenium and seleno dependent glutathione peroxidase (GPX) deficiency has been described in endemias of myxedematous cretinism. In northern Zaire, a selenium supplementation trial has been conducted. Beside correcting the GPX activity, two months of selenium supplementation was shown to modify the serum thyroid hormones parameters in clinically euthyroid subjects and to induce a dramatic fall of the already impaired thyroid function in clinically hypothyroid subjects. These results further support a role of selenium in thyroid hormone metabolism. In an iodine deficient area, this selenium deficiency could lead to opposite clinical consequences: protect the general population and the fetus against iodine deficiency and brain damage; and in turn, favour the degenerative process of the thyroid gland leading to myxoedematous cretinism.

Statistics

0204060'98'00'02'04'06'08'10'12'14'16
Citations per Year

293 Citations

Semantic Scholar estimates that this publication has 293 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Contempr1991EffectOS, title={Effect of selenium supplementation in hypothyroid subjects of an iodine and selenium deficient area: the possible danger of indiscriminate supplementation of iodine-deficient subjects with selenium.}, author={Bernard Contempr{\'e} and Jacques E. Dumont and Bảo Ng{\^o} and C{\'e}cile Thilly and Anthony T. Diplock and Jean B Vanderpas}, journal={The Journal of clinical endocrinology and metabolism}, year={1991}, volume={73 1}, pages={213-5} }