Effect of selective vagal nerve stimulation on blood pressure, heart rate and respiratory rate in rats under metoprolol medication

  title={Effect of selective vagal nerve stimulation on blood pressure, heart rate and respiratory rate in rats under metoprolol medication},
  author={Mortimer Gierthmuehlen and Dennis T. T. Plachta},
  journal={Hypertension Research},
Selective vagal nerve stimulation (sVNS) has been shown to reduce blood pressure without major side effects in rats. This technology might be the key to non-medical antihypertensive treatment in patients with therapy-resistant hypertension. β-blockers are the first-line therapy of hypertension and have in general a bradycardic effect. As VNS itself can also promote bradycardia, it was the aim of this study to investigate the influence of the β1-selective blocker Metoprolol on the effect of sVNS… 

Effect of Cardiac-Cycle-Synchronized Selective Vagal Stimulation on Heart Rate and Blood Pressure in Rats

cssVNS can chronically reduce BP in rats avoiding measurable bradycardic side effects, and this energy-efficient technique might allow the implementation of sVNS using an implantable device to permanently lower BP in patients.

Long-Term Effects of Ivabradine on Cardiac Vagal Parasympathetic Function in Normal Rats

Ivabradine significantly increased vagal modulation and shifted the sympatho-vagal balance toward vagal dominance and suggest that long-term I f blockade may protect against excessive bradycardia induced by acute vagal activation.

Electrical stimulation of the carotid sinus lowers arterial pressure and improves heart rate variability in l-NAME hypertensive conscious rats

Long-term CS stimulation is effective in reducing AP levels, improving HRV and increasing mesenteric vascular relaxation in l-NAME hypertensive rats, and only the presence of electrodes around the CS iseffective in eliciting changes in HRV similar to those observed in stimulated rats.

The role of low-level vagus nerve stimulation in cardiac therapy

It is shown that VNS is well-tolerated and safe, but the results of its efficacy are conflicting, which may well block the translational process of VNS.

Vagus nerve stimulation: state of the art of stimulation and recording strategies to address autonomic function neuromodulation — Source link

This review examines the state of the art of VNS applied to two emerging modulations of autonomic function: heart failure and obesity, especially morbid obesity and reports that VNS may benefit from improved stimulation delivery using very advanced technologies.

Influence of Clonidine on Antihypertensive Selective Afferent Vagal Nerve Stimulation in Rats

This study investigated the influence of the commonly used alpha‐2‐agonist clonidine on sVNS and found that it lowered blood pressure in rats without causing significant side effects.

Blood Pressure Change in Intrafascicular Vagal Activities

This study can shed lights on the quantified neural mechanism underlying the control of vagal activities on blood pressure, and guide the vagal-nerve neuromodulation for treating hypertension.

Vagus Nerve Stimulation and the Cardiovascular System.

The current state of preclinical and clinical studies, as well as the potential application of VNS in relation to the cardiovascular system are reviewed.

Selective Neuromodulation of the Vagus Nerve

Spatially selective VNS has the potential to achieve greater specificity and provide crucial information about vagal nerve physiology, and it is also crucial to optimize electrode array geometry and pulse shape, as well as expand the applications of sVNS beyond the current focus on cardiovascular disease.



Blood pressure control with selective vagal nerve stimulation and minimal side effects.

A novel method for selective VN stimulation to reduce BP without side effects like bradycardia and bradypnea is presented, robust to impedance changes, independent of the electrode's relative position, does not compromise the nerve and can run on implantable, ultra-low power signal processors.

BaroLoop: Using a multichannel cuff electrode and selective stimulation to reduce blood pressure

Using a multichannel cuff electrode, wrapped around a rat vagal nerve, this work was able to regulate the BP using selective, tripolar stimulation, and found that the BP took up to five times the stimulation period to recover to the value prior to stimulation.

Selective Stimulation of the Vagal Nerve Reduces Blood Pressure without Side Effects

Modulation of signals from afferent fibres from pressure sensors of the aortic arch and the carotid artery by electrical stimulation can trigger the so-called baroreflex and lower the blood pressure.

Carotid Baroreceptor Stimulation, Sympathetic Activity, Baroreflex Function, and Blood Pressure in Hypertensive Patients

Electric field stimulation of carotid sinus baroreflex afferents acutely decreased arterial blood pressure in hypertensive patients, without negative effects on physiological barore Flex regulation.

Baroreflex responses to electrical stimulation of aortic depressor nerve in conscious SHR.

Inhibition of cardiac sympathetic tone maintains reflex bradycardia during ADN stimulation in SHR despite impaired parasympathetic activation, and depressor responses toADN stimulation are equivalent or even greater inSHR due to augmented hindquarter vasodilation.

Afferent vagal nerve stimulation resets baroreflex neural arc and inhibits sympathetic nerve activity

AVNS resets the baroreflex neural arc and induces sympathoinhibition in the same manner as the control of SNA and AP by the native barore flex.

Hemodynamic responses to aortic depressor nerve stimulation in conscious L-NAME-induced hypertensive rats.

Electrical stimulation produced a well-preserved baroreflex-mediated decrease in arterial pressure and heart rate in conscious l-NAME-induced hypertensive rats and the residual fall in pressure after the triple pharmacological blockade suggests the involvement of a vasodilatory mechanism unrelated to NO or deactivation of α(1)-adrenergic receptor.

Contrasting Effects of Static and Pulsatile Pressure on Carotid Baroreceptor Activity in Dogs

Differences between the static pressure-activity curve and the pulsatile pressure- activity curve were noted during both increases and decreases in carotid sinus pressure; both curves exhibited some hysteresis during the decreases in pressure.