Effect of selective heparin desulfation on preservation of bone morphogenetic protein-2 bioactivity after thermal stress.

@article{Seto2015EffectOS,
  title={Effect of selective heparin desulfation on preservation of bone morphogenetic protein-2 bioactivity after thermal stress.},
  author={Song P. Seto and Tobias Miller and Johnna S. Temenoff},
  journal={Bioconjugate chemistry},
  year={2015},
  volume={26 2},
  pages={286-93}
}
Bone morphogenetic protein-2 (BMP-2) plays an important role in bone and cartilage formation and is of interest in regenerative medicine. Heparin can interact electrostatically with BMP-2 and thus has been explored for controlled release and potential stabilization of this growth factor in vivo. However, in its natively sulfated state, heparin has potent anticoagulant properties that may limit its use. Desulfation reduces anticoagulant properties, but may impact heparin's ability to interact… CONTINUE READING

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References

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bFGF and PDGF-BB

N. Charlton, R. H. Gelberman
2010

Minimum FGF2 binding

R. Sasisekharan, M. Guerrini
2008

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