Effect of selective estrogen receptor modulator/raloxifene analogue on proliferation and collagen metabolism of tendon fibroblast.

@article{Irie2010EffectOS,
  title={Effect of selective estrogen receptor modulator/raloxifene analogue on proliferation and collagen metabolism of tendon fibroblast.},
  author={Toru Irie and Masahiko Takahata and Tokifumi Majima and Yuichiro Abe and Miki Komatsu and Norimasa Iwasaki and Akio Minami},
  journal={Connective tissue research},
  year={2010},
  volume={51 3},
  pages={
          179-87
        }
}
The selective estrogen receptor modulator raloxifene is therapeutically beneficial for postmenopausal connective tissue degradation, such as osteoporosis, vascular sclerosis, and dermal degradation; however, the effects of raloxifene on postmenopausal tendon metabolism have not been clarified. In this study, we investigated the effects of raloxifene analogue (LY117018) on cell proliferation and collagen metabolism using cultured rat Achilles tendon fibroblasts. 17beta-Estradiol (E(2); 10(-11… CONTINUE READING
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