Effect of selection pressure for thiabendazole resistance on fitness of Haemonchus contortus in sheep.

@article{Maingi1990EffectOS,
  title={Effect of selection pressure for thiabendazole resistance on fitness of Haemonchus contortus in sheep.},
  author={N Maingi and Marilyn E. Scott and Roger K. Prichard},
  journal={Parasitology},
  year={1990},
  volume={100 Pt 2},
  pages={327-35}
}
A strain of Haemonchus contortus showing moderate levels of resistance to thiabendazole (TBZ) (egg hatch assay LC50 2.1 microM) was subjected, in alternating sequence, to 5 in vitro and 4 in vivo selections with TBZ. This resulted in a significant increase in resistance (egg hatch assay LC50 2.8 microM). The isolates obtained after each combined in vitro and in vivo selection were compared in terms of egg hatch assay, establishment, net egg output, per capita egg output and degree of pathology… CONTINUE READING

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