Corpus ID: 1920226

Effect of selected antimalarial drugs and inhibitors of cytochrome P-450 3A4 on halofantrine metabolism by human liver microsomes.

@article{Baune1999EffectOS,
  title={Effect of selected antimalarial drugs and inhibitors of cytochrome P-450 3A4 on halofantrine metabolism by human liver microsomes.},
  author={B. Baune and V. Furlan and A. Taburet and R. Farinotti},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1999},
  volume={27 5},
  pages={
          565-8
        }
}
Halofantrine (HF) is used in the treatment of uncomplicated multidrug-resistant Plasmodium falciparum malaria. Severe cardiotoxicity has been reported to be correlated with high plasma concentrations of HF but not with that of its metabolite N-debutylhalofantrine. The aim of this study was to investigate the effects of other antimalarial drugs and of ketoconazole, a typical cytochrome P-450 3A4 inhibitor, on HF metabolism by human liver microsomes. Antimalarial drug inhibitory effects were… Expand
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