Effect of secretin and caerulein in canine pancreas: relation to prostaglandins.

  title={Effect of secretin and caerulein in canine pancreas: relation to prostaglandins.},
  author={T. Homma and K. Malik},
  journal={The American journal of physiology},
  volume={244 6},
  • T. Homma, K. Malik
  • Published 1983
  • Chemistry, Medicine
  • The American journal of physiology
We investigated the effect of secretin and caerulein on pancreatic circulation and exocrine secretion and its relation to prostaglandin (PG) synthesis by studying the effect of these peptides on the pancreatic blood flow and the flow rate of pancreatic exocrine secretion in the isolated blood-perfused pancreas of pentobarbital-anesthetized dogs without or with pretreatment with the cyclooxygenase inhibitors, indomethacin and meclofenamate. Intra-arterial administration of secretin (0.1-0.3 U/kg… Expand
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