Effect of secretin, pancreozymin, histamine and Decholin® on canine pancreatic blood flow

@article{Papp2004EffectOS,
  title={Effect of secretin, pancreozymin, histamine and Decholin{\textregistered} on canine pancreatic blood flow},
  author={Mikl{\'o}s Papp and Bertalan Varga and G. Folly},
  journal={Pfl{\"u}gers Archiv},
  year={2004},
  volume={340},
  pages={349-360}
}
SummaryIf injected into the superior pancreatico-duodenal artery secretin, pancreozymin, histamine and Decholin® each significantly increases the amount of blood flowing through the artery and the pancreatic tissue. The relationship between the logs of the drug doses and their effects are linear. Whereas to histamine and Decholin® all dogs respond with the same rise in pancreatic blood flow, to pancreozymin the rate of increase was similar in all dogs and to secretin the rate of increase… 
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Observations suggest that under physiologic conditions, secretin- or 2-deoxyglucose-stimulated pancreatic secretion does not require pancreatic hyperemia, but a pharmacologic dose of secretin does produce pancreaticyperemia and peripheral cholinergic tone does not contribute significantly to basal pancreatic blood flow; and basal pancreati blood flow may be influenced by central mechanisms.
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Using epifluorescent microscopy, dynamic changes in pancreatic microcirculationin vivo after bolus administration of secretin (SEC) and cholecystokinin-octapeptide (CCK-8) in pentobarbital-anesthetized rats are investigated.
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TLDR
The results indicate that after cutting the pancreatic nerve plexus, exocrine function in the pancreas is reduced immediately but recovers within a short period of time, and that these changes in exocrinefunction are affected by blood flow in the Pancreas.
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The results suggest that both the rise in lymph flow and pressure during the development of oedema in lobular organs like the pancreas are rather the consequences and not the causes of Oedema.
Blood flow measurement in the canine pancreas.
Circulation of the pancreas and salivary glands
TLDR
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References

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The Effect of Secretin on Pancreatic Blood Flow in the Awake and Anesthetized Dog
  • R. Chung, S. Safaie-Shirazi
  • Medicine, Biology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1983
TLDR
It is concluded that increase in pancreatic blood flow is not a physiological effect of secretin, and anesthesia does not affect the blood flow response although the bicarbonate response appeared to be blunted under anesthesia.
The Interaction of Secretin and Pancreozymin on the External Pancreatic Secretion in Dogs
TLDR
Secretin and pancreozymin are shown to have a potentiating effect on the pancreatic secretion of bicarbonate, but only an additive effect onThe secretion of protein.
Role of the liver in secretin inactivation.
TLDR
The observations indicate that the effect of secretin on the pancreas is partially inactivated by the liver, and this increase in volume was highly significant statistically ( P < .005).
Relationship between pancreatic secretion and pancreatic blood flow
TLDR
An indicator fractionation technique using radioactive rubidium has been used to measure pancreatic blood flow after infusions of secretin, pancreozymin, urecholine, and pentagastrin and found increased blood flow to the remainder of the gastrointestinal organs and the perfusion rate.
Hemodynamics of pancreatic secretion. With observations on pancreatic oxygen consumption.
TLDR
It was their opinion that there was presently no evidence available to indicate that during pancreatic secretion induced by either secretin administered intravenously or hydrochloric acid administered intraduodenally, the pancreatic blood flow was increased.
Relationships between blood flow and secretion in the isolated perfused canine pancreas
TLDR
The fact that the vasodilatation was still observed when the duodenum was removed proved that the haemodynamic effect of secretin was initiated in the pancreato‐duodenal preparation or in the isolated pancreas perfused with whole heparinized blood.
Effect of Secretin Given into Portal or Peripheral Vein.∗
TLDR
It is believed that the highly purified secretin that is available now may yield more valid results than preparations made before 1926, and is assumed to indicate a primary concentration of secretin in the liver and possibly a secondary release into the circulation and to the pancreas.
Effect of Secretin in Celiac and Superior Mesenteric Angiography
  • R. Udén
  • Medicine
    Acta radiologica: diagnosis
  • 1969
TLDR
Pancreatic angiographies with administration of intra-arterial secretin in three normal cases reported that the pancreatic arteries were well demonstrated, and the greater oxygen consumption of the pancreas is associated with an increase in blood flow.
Secretin Inactivating Enzyme in Liver.∗
Summary The presence and isolation in a partially purified form of a substance from dog's liver which destroys secretin and has the characteristics of an enzyme are described; it is heat labile, does
Enzymatic Inactivation of Secretin
TLDR
The inactivation of secretin by whole blood, cell-free plasma, serum and urine has been demonstrated by Greengard and Ivy to be an enzymatic process, but it was concluded that ‘secretinase’ was not a proteolytic enzyme.
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