Effect of second- and third-generation oral contraceptives on the protein C system in the absence or presence of the factor VLeiden mutation: a randomized trial.

@article{Kemmeren2004EffectOS,
  title={Effect of second- and third-generation oral contraceptives on the protein C system in the absence or presence of the factor VLeiden mutation: a randomized trial.},
  author={Jeanet M. Kemmeren and Ale Algra and Joost C M Meijers and Guido Tans and Bonno N. Bouma and Joyce Curvers and Jan Rosing and Diederick E. Grobbee},
  journal={Blood},
  year={2004},
  volume={103 3},
  pages={927-33}
}
A plausible mechanism to explain thrombotic risk differences associated with the use of second- and third-generation oral contraceptives (OCs), particularly in carriers of factor V(Leiden), is still lacking. In a double-blind trial, 51 women without and 35 women with factor V(Leiden) were randomized to either a second- (30 microg ethinylestradiol/150 microg levonorgestrel) or third- (30 microg ethinylestradiol/150 microg desogestrel) generation OC. After 2 cycles of use and a wash-out of 2… CONTINUE READING

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