Effect of schisandrin B on hepatic glutathione antioxidant system in mice: protection against carbon tetrachloride toxicity.

@article{Ip1995EffectOS,
  title={Effect of schisandrin B on hepatic glutathione antioxidant system in mice: protection against carbon tetrachloride toxicity.},
  author={Siu Po Ip and Michel Kwong Tat Poon and Steven S Wu and Chun Tao Che and Kian Hong Ng and Y C Kong and Kam Ming Ko},
  journal={Planta medica},
  year={1995},
  volume={61 5},
  pages={
          398-401
        }
}
Pretreating female Balb/c mice with schisandrin B (Sch B) at increasing daily doses (1-4 mmol/kg) for 3 days caused dose-dependent increases in hepatic glutathione S-transferase (GST) and glutathione reductase (GRD) activities. However, the activities of glucose-6-phosphate dehydrogenase (G6PDH), Se-glutathione peroxidase (GPX), and gamma-glutamylcysteine synthetase (GCS) were down-regulated to varying degrees in a dose-dependent manner. While there were biphasic changes in hepatic reduced… CONTINUE READING

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Schizandrin prevents damage of murine mesangial cells via blocking NADPH oxidase-induced ROS signaling in high glucose.

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