Effect of salicylic acid on the plasma protein binding and pharmacokinetics of misoprostol acid.

@article{Cook1994EffectOS,
  title={Effect of salicylic acid on the plasma protein binding and pharmacokinetics of misoprostol acid.},
  author={C. Cook and G. Schoenhard and A. Karim},
  journal={Journal of pharmaceutical sciences},
  year={1994},
  volume={83 6},
  pages={
          883-6
        }
}
The in vitro serum protein binding and erythrocyte uptake of [3H]misoprostol acid ([3H]MPA; SC-30695), an active metabolite of the prostaglandin E1 (PGE1) analogue misoprostol, was determined in the blood of young (20-40 years) and elderly subjects (64 years or older) at concentrations ranging between 20 and 5000 pg/mL. The effect of selected other drugs on the displacement of [3H] MPA from the binding sites was also investigated. [3H]MPA serum binding (between 81 and 89 %) was similar and… Expand
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AND PROTEIN BINDING OF SURAMIN

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The studies presented in the present review indicate: Extensive metabolism of misoprostol occurs during and/or prior to gastrointestinal absorption, and several metabolites are formed and no unchanged drug is detected in the plasma or urine. Expand
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Abstract The method for the analysis of aspirin and salicylic acid in human plasma has been updated to include advances in column technology, extraction procedures and absorbance detection. AspirinExpand
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