Effect of salicylic acid on the plasma protein binding and pharmacokinetics of misoprostol acid.

  title={Effect of salicylic acid on the plasma protein binding and pharmacokinetics of misoprostol acid.},
  author={C. Cook and G. Schoenhard and A. Karim},
  journal={Journal of pharmaceutical sciences},
  volume={83 6},
The in vitro serum protein binding and erythrocyte uptake of [3H]misoprostol acid ([3H]MPA; SC-30695), an active metabolite of the prostaglandin E1 (PGE1) analogue misoprostol, was determined in the blood of young (20-40 years) and elderly subjects (64 years or older) at concentrations ranging between 20 and 5000 pg/mL. The effect of selected other drugs on the displacement of [3H] MPA from the binding sites was also investigated. [3H]MPA serum binding (between 81 and 89 %) was similar and… Expand
8 Citations
Misoprostol Therapeutics Revisited
Misoprostol enhances glycosoaminoglycan synthesis in cartilage after injury and reduces intraocular pressure in glaucoma and ocular hypertension, and reduces chemotherapy‐induced hair loss and recovery time from burn injury. Expand
Age-Related Changes in Protein Binding of Drugs
An understanding of the inter-relationships between drug concentrations, protein binding, the physiology of aging, disease, pharmacokinetics and pharmacodynamics is necessary for effective therapeutic monitoring and monitoring of unbound drug concentrations simplifies these relationships. Expand
Predicting Drug Binding to Human Serum Albumin and Alpha One Acid Glycoprotein in Diseased and Age Patient Populations.
The MBPM predictive model works best if the relative binding contribution of HSA and AAG is known, and a scaler for the change in protein concentration can be adjusted accordingly. Expand
Effect of Dosing Interval on the Efficacy of Misoprostol in the Prevention of Aspirin-Induced gastric Injury in the Dog
The role of prostaglandins in gastric mucosal defense and NSAID-induced gastric injury, as well as interactions between Helicobacter spp. Expand
Agents Acting on Prostanoid Receptors
The prostaglandins and thromboxanes comprise a family of C20 fatty acids, known as the prostanoids. They are primarily synthesized from arachidonic acid and exert a multitude of physiological andExpand
The effect of dosing interval on the efficacy of misoprostol in the prevention of aspirin-induced gastric injury.
It is suggested that misoprostol 3 microg/kg PO q12h is as effective as misop Frostol 3microg/ kg PO q8h in preventing aspirin-induced gastric injury in this model, however, misop frostol was less effective in preventing Aspirin-induced Gastric injury on days 14 and 28 than in previous studies. Expand
Acute hemolytic anemia with acanthocytosis associated with high-dose misoprostol for medical abortion.
The present case suggests that high-dose misoprostol, a prostaglandin E1 analogue, severely affects RBC features and causes an acquired acute hemolytic anemia, which is self-limited when misop frostol is withdrawn. Expand


Antiulcer prostaglandin misoprostol: single and multiple dose pharmacokinetic profile.
The studies presented in the present review indicate: Extensive metabolism of misoprostol occurs during and/or prior to gastrointestinal absorption, and several metabolites are formed and no unchanged drug is detected in the plasma or urine. Expand
Protein binding of salicylate in uremic and normal plasma
In addition to the effect of the uremic state, the binding was considerably decreased at high therapeutic plasma levels and at low albumin levels, which should be considered in the monitoring of plasma salicylate levels in patients. Expand
Perspective on the gastric antisecretory effects of misoprostol in man.
The gastric antisecretory effects of misoprostol in healthy human subjects using randomized, double-blind, placebo-controlled studies are summarized and it is concluded that misobrostol is a potent inhibitor of gastric acid secretion in man. Expand
Misoprostol: Discovery, development, and clinical applications
Misoprostol effectively heals and prevents NSAID-induced gastropathy, a therapeutic need previously unserved, and may have advantages over antisecretory drugs in the compromised patient who is a chronic smoker or alcohol user, in refractory duodenal ulcer patients, in recurrent ulcer, and in emergency use for acute upper GI bleeding. Expand
Revised Method for Determination of Aspirin and Salicylic Acid in Human Plasma by High Pressure Liquid Chromatography
Abstract The method for the analysis of aspirin and salicylic acid in human plasma has been updated to include advances in column technology, extraction procedures and absorbance detection. AspirinExpand
Overview of the mucosal protective effects of misoprostol in man.
Misoprostol, a novel synthetic analog of prostaglandin E1 has been evaluated for its potential mucosal protective properties in healthy human subjects using randomized, double-blind,Expand