Effect of salicylates on cyclic AMP in isolated rat gastric mucosa.

@article{Mitznegg1977EffectOS,
  title={Effect of salicylates on cyclic AMP in isolated rat gastric mucosa.},
  author={P. Mitznegg and Cody J Estler and Friedrich Loew and J van Seil},
  journal={Acta hepato-gastroenterologica},
  year={1977},
  volume={24 5},
  pages={372-6}
}
Studies on the cyclic AMP content of isolated rat gastric mucosa have been conducted with sodium salicylate and lysine-acetylsalicylate singly and combined with gastric secretagogues and their antagonists. Both salicylates at a concentration of 1.66 X 10(-2) M increased the amount of cyclic AMP. The increase of gastric mucosal cyclic AMP produced by sodium salicylate was diminished by prostaglandin E1 (10(-5) M), atropine (10(-6) M) and the H2-antihistamine metiamide (2 X 10(-4) M… CONTINUE READING