Effect of rutin on polymorphonuclear leukocytes oxidative metabolism in hypercholesterolemic Golden Syrian hamsters: evaluation by chemiluminescence and flow cytometry.

@article{Kanashiro2007EffectOR,
  title={Effect of rutin on polymorphonuclear leukocytes oxidative metabolism in hypercholesterolemic Golden Syrian hamsters: evaluation by chemiluminescence and flow cytometry.},
  author={Alexandre Kanashiro and Luciana Mariko Kabeya and Fl{\'a}via Martinello and Walter Miguel Turato and Fabiana da Silva Paula and Ana Christina Morseli Polizello and S{\'e}rgio Akira Uyemura and Yara Maria Lucisano-Valim},
  journal={Die Pharmazie},
  year={2007},
  volume={62 4},
  pages={
          295-8
        }
}
Atherosclerosis has been described as an inflammatory disease in which polymorphonuclear leukocytes (PMNLs) seem to be involved. These cells may induce atherosclerotic lesions by releasing reactive oxygen species (ROS) and a sort of pro-inflammatory mediators. In this study, the PMNL oxidative metabolic status of Golden Syrian hamsters fed a normal diet (ND), or a high-fat diet (10% coconut oil plus 0.2% cholesterol) supplemented (R-HCD) or not (HCD) with 0.1% (w/w) rutin was evaluated after… CONTINUE READING