Effect of roxithromycin on mucosal damage, oxidative stress and pro-inflammatory markers in experimental model of colitis

@article{Ahmad2017EffectOR,
  title={Effect of roxithromycin on mucosal damage, oxidative stress and pro-inflammatory markers in experimental model of colitis},
  author={Hilal Ahmad and S. Verma and V. Kumar},
  journal={Inflammation Research},
  year={2017},
  volume={67},
  pages={147-155}
}
  • Hilal Ahmad, S. Verma, V. Kumar
  • Published 2017
  • Medicine
  • Inflammation Research
  • Objective and designRoxithromycin, a macrolide antibiotic, exhibits anti-inflammatory property. The present study was designed to evaluate its protective effect in a rat model of colitis.MethodsThe anti-inflammatory property of roxithromycin was first validated in rat paw edema model at 5 and 20 mg/kg doses where it produced 19 and 51% inhibition of paw swelling induced by carrageenan. The efficacy of roxithromycin was evaluated at these doses in a rat model where colitis was induced by intra… CONTINUE READING
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