Effect of route of administration of fluconazole on the interaction between fluconazole and midazolam

@article{Ahonen1997EffectOR,
  title={Effect of route of administration of fluconazole on the interaction between fluconazole and midazolam},
  author={Jukka-Pekka Ahonen and Klaus T. Olkkola and Pertti J Neuvonen},
  journal={European Journal of Clinical Pharmacology},
  year={1997},
  volume={51},
  pages={415-419}
}
Midazolam is a short-acting benzodiazepine hypnotic extensively metabolized by CYP3A4 enzyme. Orally ingested azole antimycotics, including fluconazole, interfere with the metabolism of oral midazolam during its absorption and elimination phases. We compared the effect of oral and intravenous fluconazole on the pharmacokinetics and pharmacodynamics of orally ingested midazolam. A double-dummy, randomized, cross-over study in three phases was performed in 9 healthy volunteers. The subjects were… CONTINUE READING
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Effect of azole antifungals on human microsomal metabolism of diclofenac and midazolam

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