Effect of rosuvastatin therapy on carotid plaque morphology and composition in moderately hypercholesterolemic patients: a high-resolution magnetic resonance imaging trial.

@article{Underhill2008EffectOR,
  title={Effect of rosuvastatin therapy on carotid plaque morphology and composition in moderately hypercholesterolemic patients: a high-resolution magnetic resonance imaging trial.},
  author={Hunter R. Underhill and Chun Yuan and X Q Zhao and Larry W. Kraiss and Dennis L. Parker and T. Saam and Baocheng Chu and Norihide Takaya and Fei Liu and Nayak Polissar and Blazej Neradilek and Joel S. Raichlen and Valerie A. Cain and John C. Waterton and Wendy K Hamar and Thomas S. Hatsukami},
  journal={American heart journal},
  year={2008},
  volume={155 3},
  pages={584.e1-8}
}
BACKGROUND Magnetic resonance imaging (MRI) can noninvasively assess changes in atherosclerotic plaque morphology and composition. The ORION trial assessed the effects of rosuvastatin on carotid plaque volume and composition. METHODS The randomized, double-blind ORION trial used 1.5-T MRI to image carotid atherosclerotic plaques at baseline and after 24 months of treatment. Forty-three patients with fasting low-density lipoprotein cholesterol > or = 100 and < 250 mg/dL and 16% to 79% carotid… CONTINUE READING
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