Effect of rosuvastatin on hepatic production of apolipoprotein B-containing lipoproteins in an animal model of insulin resistance and metabolic dyslipidemia.

@article{Chong2006EffectOR,
  title={Effect of rosuvastatin on hepatic production of apolipoprotein B-containing lipoproteins in an animal model of insulin resistance and metabolic dyslipidemia.},
  author={Taryne M Chong and Mark Naples and Lisa M Federico and Denise Taylor and Graham J Smith and Raphael C Cheung and Khosrow Adeli},
  journal={Atherosclerosis},
  year={2006},
  volume={185 1},
  pages={21-31}
}
A novel animal model of insulin resistance, the fructose-fed Syrian golden hamster, was employed to investigate the efficacy and mechanisms of action of rosuvastatin, a HMG-CoA reductase inhibitor, in ameliorating metabolic dyslipidemia in insulin-resistant states. Fructose feeding for a 2-week period induced insulin resistance and a significant increase in hepatic secretion of VLDL. This was followed by a fructose-enriched diet with or without 10 mg/kg rosuvastatin for 14 days. Fructose… CONTINUE READING
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