Effect of rifampin on plasma concentrations of mefloquine in healthy volunteers.

  title={Effect of rifampin on plasma concentrations of mefloquine in healthy volunteers.},
  author={Wibool Ridtitid and Malinee Wongnawa and Werawath Mahatthanatrakul and P Chaipol and Methi Sunbhanich},
  journal={The Journal of pharmacy and pharmacology},
  volume={52 10},
Mefloquine is a 4-quinolinemethanol compound structurally related to quinine. Quinine is mainly metabolized by the cytochrome P450 3A4 isozyme (CYP3A4), whereas rifampin, a potent inducer of CYP3A4, is known to markedly decrease plasma quinine concentration. Our aim was to study the effect of rifampin on the pharmacokinetics of mefloquine, and explore a possible role of CYP3A4 on mefloquine metabolism. In an open, two-phase crossover study, seven healthy Thai male volunteers received a single… CONTINUE READING

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