Effect of rifampicin on the pharmacokinetics of pioglitazone.

  title={Effect of rifampicin on the pharmacokinetics of pioglitazone.},
  author={Tiina Jaakkola and Janne T. Backman and Mikko Neuvonen and Jouko Laitila and Pertti J Neuvonen},
  journal={British journal of clinical pharmacology},
  volume={61 1},
AIMS The effect of enzyme induction on the pharmacokinetics of pioglitazone, a thiazolidinedione antidiabetic drug that is metabolized primarily by CYP2C8, is not known. Rifampicin is a potent inducer of several CYP enzymes and our objective was to study its effects on the pharmacokinetics of pioglitazone in humans. METHODS In a randomized, two-phase crossover study, ten healthy subjects ingested either 600 mg rifampicin or placebo once daily for 6 days. On the last day, they received a… CONTINUE READING

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