Effect of rifampicin-based antitubercular therapy on nevirapine plasma concentrations in South African adults with HIV-associated tuberculosis.

@article{Cohen2008EffectOR,
  title={Effect of rifampicin-based antitubercular therapy on nevirapine plasma concentrations in South African adults with HIV-associated tuberculosis.},
  author={Karen L. Cohen and Gilles van Cutsem and Andrew A Boulle and Helen Margaret McIlleron and Eric Goemaere and Peter John Smith and Gary Maartens},
  journal={The Journal of antimicrobial chemotherapy},
  year={2008},
  volume={61 2},
  pages={389-93}
}
BACKGROUND AND OBJECTIVES Nevirapine-containing antiretroviral therapy (ART) and rifampicin-based antitubercular therapy are commonly co-administered in Africa, where nevirapine is often the only available non-nucleoside reverse transcriptase inhibitor. Rifampicin induces the metabolism of nevirapine, but the extent of the reduction in nevirapine concentrations has varied widely in previous studies. We describe the steady-state pharmacokinetics of nevirapine during and after antitubercular… CONTINUE READING

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