Effect of ribose cysteine pretreatment on hepatic and renal acetaminophen metabolite formation and glutathione depletion.

@article{Slitt2005EffectOR,
  title={Effect of ribose cysteine pretreatment on hepatic and renal acetaminophen metabolite formation and glutathione depletion.},
  author={Angela M Lucas Slitt and Pamela K Dominick and Jeanette C. Roberts and Steven D. Cohen},
  journal={Basic & clinical pharmacology & toxicology},
  year={2005},
  volume={96 6},
  pages={487-94}
}
Ribose cysteine (2(R,S)-D-ribo-(1',2',3',4'-tetrahydroxybutyl)thiazolidine-4(R)-carboxylic acid) protects against acetaminophen-induced hepatic and renal toxicity. The mechanism for this protection is not known, but may involve inactivation of the toxic electrophile via enhancement of glutathione (GSH) biosynthesis. Therefore, the goal of this study was to determine if GSH biosynthesis was required for the ribose cysteine protection. Male CD-1 mice were injected with either acetaminophen or… CONTINUE READING

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