Effect of ribavirin on viral kinetics and liver gene expression in chronic hepatitis C.

  title={Effect of ribavirin on viral kinetics and liver gene expression in chronic hepatitis C.},
  author={Yaron Rotman and M Noureddin and Jordan J Feld and J{\'e}r{\'e}mie Guedj and Michael W Witthaus and Hwalih Han and Yoon Jung Park and S Park and Theo Heller and Marc G Ghany and Edward C Doo and Christopher K. H. Koh and Adil Abdalla and Naveen Gara and Souvik Sarkar and Emmanuel Thomas and Golo Ahlenstiel and Birgit Edlich and Rachel H Titerence and Leah J Hogdal and Barbara Rehermann and Harel Dahari and Alan S. Perelson and Jay H. Hoofnagle and T. Jake Liang},
  volume={63 1},
OBJECTIVE Ribavirin improves treatment response to pegylated-interferon (PEG-IFN) in chronic hepatitis C but the mechanism remains controversial. We studied correlates of response and mechanism of action of ribavirin in treatment of hepatitis C. DESIGN 70 treatment-naive patients were randomised to 4 weeks of ribavirin (1000-1200 mg/d) or none, followed by PEG-IFNα-2a and ribavirin at standard doses and durations. Patients were also randomised to a liver biopsy 24 h before or 6 h after… CONTINUE READING
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