Effect of ribavirin on the replication of infectious pancreatic necrosis virus in fish cell cultures.

@article{Migus1980EffectOR,
  title={Effect of ribavirin on the replication of infectious pancreatic necrosis virus in fish cell cultures.},
  author={D O Migus and P{\'e}ter Dobos},
  journal={The Journal of general virology},
  year={1980},
  volume={47 1},
  pages={
          47-57
        }
}
Ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) at concentrations of 10 microgram/ml or more, inhibited the replication of infectious pancreatic necrosis virus (IPNV) in both Chinook salmon embryo (CHSE-214) and rainbow trout gonad (RTG-2) cells. The drug was most effective when added just before or within 8 h p.i. Incorporation studies with radioactive precursors demonstrated that ribavirin suppressed cellular DNA and RNA synthesis within 2 to 3 h after addition of the drug… 
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References

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TLDR
The broad spectrum antiviral drug ribavirin inhibits cellular macromolecular synthesis as well as cell division in eucaryotic cells and can be reversed by removing the drug from the cells.
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TLDR
The physicochemical and serological properties of a virus isolated from the bivalve mollusc, Tellina tenuis, and the close similarity in morphology and physiochemical properties suggests that Tellina virus and IPN virus belong to the same virus group.
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The RNA from infectious pancreatic necrosis virus has been purified and had a sedimentation velocity of 14S on sucrose gradients, a buoyant density of 1-60 g/ml in CS2SO4 and pyrimidine to purine…
Size and structure of the genome of infectious pancreatic necrosis virus.
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    Nucleic acids research
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TLDR
Since infectious pancreatic necrosis virus contains only two dsRNA segments it does not belong to the family Reoviridae and may represent a new group of viruses, indicating the absence of exposed single strainded regions in the viral genome.
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Virazole is a synthetic nucleoside active in tissue culture against at least 16 DNA and RNA viruses. Applied topically, it inhibits herpetic keratitis in rabbits and tail lesions induced by herpes,…
Mechanism of action of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole), a new broad-spectrum antiviral agent.
TLDR
Results suggest that the antiviral activity of Virazole might be due to the inhibition of GMP biosynthesis in the infected cell at the step involving the conversion of IMP to xanthosine 5'-phosphate, which would result in inhibition of the synthesis of vital viral nucleic acid.
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TLDR
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TLDR
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TLDR
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