Effect of retreatment with interferon alone or interferon plus ribavirin on hepatitis C virus quasispecies diversification in nonresponder patients with chronic hepatitis C.

@article{Gerotto1999EffectOR,
  title={Effect of retreatment with interferon alone or interferon plus ribavirin on hepatitis C virus quasispecies diversification in nonresponder patients with chronic hepatitis C.},
  author={Martina Gerotto and Daniel G. Sullivan and Stephen J. Polyak and Liliana Chemello and Luisa Cavalletto and Patrizia Pontisso and Alfredo Alberti and David R. Gretch},
  journal={Journal of virology},
  year={1999},
  volume={73 9},
  pages={7241-7}
}
Alpha interferon (IFN-alpha) treatment is effective on a long-term basis in only 15 to 25% of patients with chronic hepatitis C. The results of recent trials indicate that response rates can be significantly increased when IFN-alpha is given in combination with ribavirin. However, a large number of patients do not respond even to combination therapy. Nonresponsiveness to IFN is characterized by evolution of the hepatitis C virus (HCV) quasispecies. Little is known about the changes occurring… CONTINUE READING
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