Effect of retinoid deficiency on keratin expression in mouse bladder.

@article{Molloy1988EffectOR,
  title={Effect of retinoid deficiency on keratin expression in mouse bladder.},
  author={Christopher J. Molloy and Jeffrey D Laskin},
  journal={Experimental and molecular pathology},
  year={1988},
  volume={49 1},
  pages={128-40}
}
Twelve to sixteen weeks following treatment of CF-1 mice with a vitamin A-deficient diet, characteristic signs of retinoid deficiency including body wasting, poor hair coat, altered gait, decreased mobility, and xerophthalmia were observed. Histological examination of tissue sections from these mice revealed dramatic changes in the urinary tract epithelium. The normal transitional epithelium was replaced by a stratified squamous epithelium that resembled hyperproliferative epidermis. Using two… CONTINUE READING