Effect of resveratrol supplementation on cognitive performance and mood in adults: a systematic literature review and meta-analysis of randomized controlled trials

@article{Marx2018EffectOR,
  title={Effect of resveratrol supplementation on cognitive performance and mood in adults: a systematic literature review and meta-analysis of randomized controlled trials},
  author={Wolfgang Marx and Jaimon T Kelly and Skye Marshall and Jennifer Cutajar and Brigitte Annois and Andrew Pipingas and Audrey C. Tierney and Catherine Itsiopoulos},
  journal={Nutrition Reviews},
  year={2018},
  volume={76},
  pages={432–443}
}
Context The aim of this systematic review was to evaluate clinical trial data regarding the effect of resveratrol supplementation on cognitive performance and mood in populations that are healthy and in the clinical setting. Data Sources Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic literature review of randomized controlled trials was conducted. Data Extraction A meta-analysis was also conducted to determine treatment effect… Expand

Figures, Tables, and Topics from this paper

The effect of blueberry interventions on cognitive performance and mood: A systematic review of randomized controlled trials
TLDR
Based on the current evidence, blueberries may improve some measures of cognitive performance, however, considerable differences in study design, dosages, and anthocyanin content hinder between-study comparison. Expand
The Effect of Adjunctive Mangosteen Pericarp on Cognition in People With Schizophrenia: Secondary Analysis of a Randomized Controlled Trial
TLDR
Mangosteen pericarp extract did not affect cognitive outcomes in people with schizophrenia and further investigation regarding optimal dosing strategies for mangosteen interventions and the testing of additional cognitive domains may be warranted. Expand
Resveratrol: A “miracle” drug in neuropsychiatry or a cognitive enhancer for mice only? A systematic review and meta-analysis
TLDR
The effects, if any, of resveratrol on human cognition are likely to be small and may be useful for the design and implementation of future pre-clinical and clinical studies using resver atrol in a neurological setting. Expand
The Cognitive Effects of the Polyphenol Resveratrol in Young, Healthy Humans: A Review of Six Balanced Crossover, Placebo Controlled, Double Blind Trials
TLDR
The results of this summary paper definitively confirms that 500 mg resveratrol does not acutely improve a wide range of cognitions in healthy, 18-35 year old humans. Expand
The effects of resveratrol supplementation in patients with type 2 diabetes, metabolic syndrome, and nonalcoholic fatty liver disease: an umbrella review of meta-analyses of randomized controlled trials.
TLDR
Current evidence does not support supplementation with resveratrol for the management of cardiometabolic risk factors in patients with T2D, MetS, and NAFLD. Expand
Polyphenols and Cognition In Humans: An Overview of Current Evidence from Recent Systematic Reviews and Meta-Analyses
TLDR
The current evidence base does not support reliable conclusions relating to efficacy of specific doses, duration of treatment, or sensitivity in specific populations or certain cognitive domains, such that the conclusion is tentative, and by no means definitive. Expand
Polyphenol Health Effects on Cardiovascular and Neurodegenerative Disorders: A Review and Meta-Analysis
TLDR
Although some polyphenols might improve specific markers of cardiovascular risk and cognitive status, many inconsistent data are present in literature, therefore, definitive recommendations for the use of these compounds in the prevention of cardiovascular disease and cognitive decline are currently not applicable. Expand
Use of GRADE in evidence syntheses published in high-impact-factor nutrition journals: a methodological survey.
TLDR
A need for directing more attention towards strengthening acceptance of GRADE as well as building knowledge of the GRADE methodology in nutrition evidence synthesis is suggested. Expand
Polyphenols as adjunctive treatments in psychiatric and neurodegenerative disorders: efficacy, mechanisms of action, and factors influencing inter-individual response.
TLDR
The aim of this review is to highlight the emerging clinical trial and preclinical efficacy data regarding the role of polyphenols in mental and brain health, elucidate novel mechanisms of action including the gut microbiome and gene expression, and discuss the factors that may be responsible for the mixed clinical results. Expand
Understanding the relationship between oxidative stress and cognition in the elderly
TLDR
It is concluded that while there is some evidence that nutraceuticals with antioxidant activity may reduce cognitive decline, and that there are plausible biological mechanisms by which this may occur, large and long-term clinical trials are lacking and results are somewhat inconsistent. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 42 REFERENCES
Resveratrol Supplementation Did Not Improve Cognition in Patients with Schizophrenia: Results from a Randomized Clinical Trial
TLDR
It is shown that 1 month of a resveratrol supplementation did not improve episodic memory, working memory, attention and concentration capacity, inhibitory control, interference measures, selective attention, and mental flexibility as compared with placebo in patients with SZ. Expand
The effects of chronic trans-resveratrol supplementation on aspects of cognitive function, mood, sleep, health and cerebral blood flow in healthy, young humans
TLDR
The results confirm the acute CBF effects of resveratrol and the lack of interpretable cognitive effects. Expand
Effects of Resveratrol on Cognitive Performance, Mood and Cerebrovascular Function in Post-Menopausal Women; A 14-Week Randomised Placebo-Controlled Intervention Trial
TLDR
Regular consumption of a modest dose of resveratrol can enhance both cerebrovascular function and cognition in post-menopausal women, potentially reducing their heightened risk of accelerated cognitive decline and offering a promising therapeutic treatment for menopause-related cognitive decline. Expand
A Review of the Cognitive Effects Observed in Humans Following Acute Supplementation with Flavonoids, and Their Associated Mechanisms of Action
TLDR
Overall, there is encouraging evidence that flavonoid supplementation can benefit cognitive outcomes within an acute time frame of 0–6 h, but larger studies, combining cognitive and physiological measures, are needed to strengthen the evidence base. Expand
Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation.
TLDR
Results showed that single doses of orally administered resveratrol can modulate cerebral blood flow variables and modulate brain function in healthy human adults. Expand
Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation
TLDR
The results indicated that when co-supplemented, piperine and resveratrol significantly augmented CBF during task performance in comparison with placebo and res veratrol alone, and does this without altering bioavailability, and cognitive function, mood and blood pressure were not affected. Expand
Effects of resveratrol and alcohol on mood and cognitive function in older individuals
TLDR
Compared with red wine alone, resveratrol-enriched wine was associated with significantly enhanced Serial Sevens performance and redwine alone resulted in better performance during Serial Threes, suggesting increased blood flow from resver atrol and the documented stimulant effects of alcohol at low levels. Expand
The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration
TLDR
The meaning and rationale for each checklist item is explained, and an example of good reporting is included and, where possible, references to relevant empirical studies and methodological literature are included. Expand
Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Study—a randomized controlled trial1234
TLDR
This dietary intervention study provides evidence that regular CF consumption can reduce some measures of age-related cognitive dysfunction, possibly through an improvement in insulin sensitivity, and suggests that the habitual intake of flavanols can support healthy cognitive function with age. Expand
Effects of Resveratrol on Memory Performance, Hippocampal Functional Connectivity, and Glucose Metabolism in Healthy Older Adults
TLDR
Initial evidence is provided that supplementary resveratrol improves memory performance in association with improved glucose metabolism and increased hippocampal FC in older adults, offering the basis for novel strategies to maintain brain health during aging. Expand
...
1
2
3
4
5
...