Effect of restraint stress on immune system and experimental B16 melanoma metastasis in aged mice.

@article{Kanno1997EffectOR,
  title={Effect of restraint stress on immune system and experimental B16 melanoma metastasis in aged mice.},
  author={Jun Kanno and Atsuko Wakikawa and Masanori Utsuyama and Katsuiku Hirokawa},
  journal={Mechanisms of ageing and development},
  year={1997},
  volume={93 1-3},
  pages={107-17}
}
An overnight restraint stress was given to young and old mice and its effect was examined in terms of the number and function of T cells and natural killer (NK) cells in spleen and patterns of lung metastasis of B16 melanoma cells. A great decrease was observed in the number and proliferative activity of splenic T cells in old mice after the stress. The… CONTINUE READING