Effect of respiratory syncytial virus on subsequent allergic sensitization to ovalbumin in guinea-pigs.

@article{Dakhama1999EffectOR,
  title={Effect of respiratory syncytial virus on subsequent allergic sensitization to ovalbumin in guinea-pigs.},
  author={Azzeddine Dakhama and Andrew M Bramley and Nancy G Chan and Karen Olwyn McKay and R. Robert Schellenberg and Richard G. Hegele},
  journal={The European respiratory journal},
  year={1999},
  volume={13 5},
  pages={976-82}
}
Children with acute respiratory syncytial virus (RSV) bronchiolitis often develop recurrent wheezing, asthma and allergic sensitization, but the role of RSV in the pathogenesis of these sequelae is unclear. This study examined whether RSV infection potentiates subsequent allergic sensitization, airway hyperresponsiveness (AHR) and airway inflammation induced by repeated exposures to aerosolized ovalbumin (OA) in guinea-pigs. Guinea-pigs received either RSV or sham inoculum, followed by… CONTINUE READING

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