Effect of reserpine on adenylate cyclase system of rat striatum

We have investigated the properties of dopamine-dependent adenylate cyclase in rat striatal homogenates, 20 h after reserpine treatment. In this experimental condition, we have found that the affinity of the enzyme for dopamine is greatly enhanced. On the other hand, the concentration of apomorphine required to produced half-maximal activation of the enzyme… CONTINUE READING