Effect of repeated treatment with tianeptine and fluoxetine on the central alpha(1)-adrenergic system.

@article{Rog2001EffectOR,
  title={Effect of repeated treatment with tianeptine and fluoxetine on the central alpha(1)-adrenergic system.},
  author={Zofia Rog{\'o}ż and Grażyna Skuza and Daniel Dlaboga and Jerzy Maj and Marta Dziedzicka-Wasylewska},
  journal={Neuropharmacology},
  year={2001},
  volume={41 3},
  pages={360-8}
}
Tianeptine (TIA) is an antidepressant drug which enhances the reuptake of serotonin but, in contrast to tricyclics, shows no affinity for neurotransmitter receptors. The present study was aimed at determining whether repeated TIA treatment induced adaptive changes in the alpha(1)-adrenergic system, similar to those reported by us earlier for tricyclic antidepressants. The experiments were carried out on male mice and rats. TIA was administered at a dose of 5 or 10mg/kg once or repeatedly (twice… CONTINUE READING