• Corpus ID: 2632064

Effect of repeated treatment with reboxetine on the central alpha 1-adrenergic and dopaminergic receptors.

@article{Rog2002EffectOR,
  title={Effect of repeated treatment with reboxetine on the central alpha 1-adrenergic and dopaminergic receptors.},
  author={Zofia Rog{\'o}ż and Wojciech Margas and Grażyna Skuza and Joanna Solich and Maciej Kuśmider and Marta Dziedzicka-Wasylewska},
  journal={Polish journal of pharmacology},
  year={2002},
  volume={54 6},
  pages={
          593-603
        }
}
Reboxetine (REB) is a member of a new class of antidepressant drugs, which selectively inhibit the neuronal reuptake of noradrenaline. It is devoid of any affinity for neurotransmitter receptors nor does it inhibit monoamine oxidases A or B. Since our earlier studies have shown that antidepressant drugs administered repeatedly increase the responsiveness of alpha1-adrenergic receptors and induce the up-regulation of postsynaptic dopamine D2/D3 receptors in the rat brain, we designed the present… 
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