Effect of repeated electroconvulsive shocks on serotonergic neurons.

  title={Effect of repeated electroconvulsive shocks on serotonergic neurons.},
  author={Pierre Blier and Claude Bouchard},
  journal={European journal of pharmacology},
  volume={211 3},
The hypothermia induced by the serotonin (5-HT)1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) was attenuated in rats that had received a course of six electroconvulsive shocks (ECS) over a two-week period. The firing activity of dorsal raphe 5-HT neurons, as well as their responsiveness to microiontophoretic applications of 5-HT and 8-OH-DPAT, was unaltered in ECS-treated rats. The electrically evoked overflow of [3H]5-HT from preloaded slices of guinea pig hypothalamus… CONTINUE READING
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