Effect of repeated doses of ethanol on hepatic Mg2+ homeostasis and mobilization.

@article{Young2007EffectOR,
  title={Effect of repeated doses of ethanol on hepatic Mg2+ homeostasis and mobilization.},
  author={Andrew B. Young and Liliana N. Berti-Mattera and Andrea M.P. Romani},
  journal={Alcoholism, clinical and experimental research},
  year={2007},
  volume={31 7},
  pages={
          1240-51
        }
}
The acute administration of a first dose of ethanol (EtOH) to rat liver cells reduces the amount of Mg(2+) extruded by a second dose of EtOH or the subsequent addition of adrenergic agonists. In contrast, the Mg(2+) extrusion normally elicited by the alpha(1)-adrenergic or beta-adrenergic agonist does not impair the Mg(2+) mobilization induced by the subsequent addition of EtOH. Inhibition of EtOH metabolism by 4-methylpyrazole abolishes almost completely the Mg(2+) extrusion induced by the… CONTINUE READING
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