Effect of renal impairment on the pharmacokinetics of a single oral dose of tibolone 2.5 mg in early postmenopausal women.

@article{Timmer2002EffectOR,
  title={Effect of renal impairment on the pharmacokinetics of a single oral dose of tibolone 2.5 mg in early postmenopausal women.},
  author={Cees J. Timmer and Dennis P Doorstam},
  journal={Pharmacotherapy},
  year={2002},
  volume={22 2},
  pages={148-53}
}
STUDY OBJECTIVE To determine the influence of renal function on the pharmacokinetics of tibolone and its primary metabolites, delta4-tibolone, 3alpha-hydroxytibolone, and 3beta-hydroxytibolone. DESIGN Open-label, single-center, single-dose study SETTING Drug research center, Balatonfüred, Hungary. SUBJECTS Twenty-four postmenopausal women aged 45-65 years. INTERVENTION Subjects were assigned to one of four groups based on their renal function, as assessed by glomerular filtration rate… CONTINUE READING

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