Effect of renal impairment on the pharmacokinetics of exenatide

  title={Effect of renal impairment on the pharmacokinetics of exenatide},
  author={Helle Linnebjerg and Prajakti A. Kothare and Soomin Park and Kenneth F. Mace and S. Rajendra Reddy and Malcolm Mitchell and Robert Lins},
  journal={British Journal of Clinical Pharmacology},
  pages={317 - 327}
AIMS To evaluate the pharmacokinetics (PK), safety and tolerability of a single exenatide dose in patients with renal impairment (RI). METHODS Exenatide (5 or 10 microg) was injected subcutaneously in 31 subjects (one with Type 2 diabetes) stratified by renal function [Cockcroft-Gault creatinine clearance (CrCL), number of subjects]: normal (>80 ml min(-1), n = 8), mild RI (51-80 ml min(-1), n = 8), moderate RI (31-50 ml min(-1), n = 7) or end-stage renal disease (ESRD) requiring… CONTINUE READING
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