Effect of renal excretion rate on intrarenal distribution of sulfonamides

Abstract

A study of the distribution of sulfadimethoxine and sulfisoxazole in plasma, kidney cortex and medullopapillary tissue is presented. Equimolar amounts of each sulfonamide were fed to separate groups of hydropenic rats, and measurements carried out after one hour and five hours. Similar plasma concentrations of either drug were encountered one hour after the… (More)
DOI: 10.1007/BF01002381

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