Effect of relA function on the replication of plasmid pBR322 in Escherichia coli

  title={Effect of relA function on the replication of plasmid pBR322 in Escherichia coli},
  author={Sue Lin-Chao and H. -J. Bremer},
  journal={Molecular and General Genetics MGG},
Replication of the plasmid pBR322, and the accumulation and life time of its primer transcript, RNAII, and replication inhibitor, RNAI, were measured in an isogenic relA + /relA pair of E. coli strains during exponential growth, or following amino acid starvation, or during treatment with chloramphenicol. (1) The synthesis rates of RNAI and RNAII decreased during inhibition of protein synthesis in either strain, i.e. their promoters are not under stringent control; (2) during amino acid… CONTINUE READING

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