Effect of regulating cholesterol biosynthesis on breath isoprene excretion in men

@article{Stone1993EffectOR,
  title={Effect of regulating cholesterol biosynthesis on breath isoprene excretion in men},
  author={Bradford G. Stone and Timothy J. Besse and William C. Duane and Christopher C D Evans and Eugene G Demaster},
  journal={Lipids},
  year={1993},
  volume={28},
  pages={705-708}
}
Isoprene is a normal constituent of human breath and may be derived from the cholesterol synthetic pathway. Acute and chronic lovastatin and a cholesterol-supplemented diet were used to determine whether a mechanistic link exists between isoprene and cholesterol biosynthesisin vivo in humans. The acute effects of lovastatin, a competitive inhibitor of the rate-limiting step of cholesterol biosynthesis, on breath isoprene excretion was determined by administering a single 20, 40 or 80 mg dose of… CONTINUE READING

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