Effect of regional lung inflation on ventilation heterogeneity at different length scales during mechanical ventilation of normal sheep lungs.

@article{Wellman2012EffectOR,
  title={Effect of regional lung inflation on ventilation heterogeneity at different length scales during mechanical ventilation of normal sheep lungs.},
  author={Tyler J. Wellman and Tilo Winkler and Eduardo L. V. Costa and Guido Musch and Robert Scott Harris and Jose Gabriel Venegas and Marcos Francisco Vidal Melo},
  journal={Journal of applied physiology},
  year={2012},
  volume={113 6},
  pages={947-57}
}
Heterogeneous, small-airway diameters and alveolar derecruitment in poorly aerated regions of normal lungs could produce ventilation heterogeneity at those anatomic levels. We modeled the washout kinetics of (13)NN with positron emission tomography to examine how specific ventilation (sV) heterogeneity at different length scales is influenced by lung aeration. Three groups of anesthetized, supine sheep were studied: high tidal volume (Vt; 18.4 ± 4.2 ml/kg) and zero end-expiratory pressure (ZEEP… CONTINUE READING

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