Effect of recombinant surfactant protein C-based surfactant on the acute respiratory distress syndrome.

@article{Spragg2004EffectOR,
  title={Effect of recombinant surfactant protein C-based surfactant on the acute respiratory distress syndrome.},
  author={Roger G. Spragg and James F. Lewis and H. D. Walmrath and Jay A Johannigman and Geoff J Bellingan and P. -F. Laterre and Michael C Witte and Guy Antony Richards and Gerd Rippin and Frank E. Rathgeb and Dietrich Haefner and Friedemann J H Taut and Werner Seeger},
  journal={The New England journal of medicine},
  year={2004},
  volume={351 9},
  pages={884-92}
}
BACKGROUND Preclinical studies suggest that exogenous surfactant may be of value in the treatment of the acute respiratory distress syndrome (ARDS), and two phase 2 clinical trials have shown a trend toward benefit. We conducted two phase 3 studies of a protein-containing surfactant in adults with ARDS. METHODS In two multicenter, randomized, double-blind trials involving 448 patients with ARDS from various causes, we compared standard therapy alone with standard therapy plus up to four… CONTINUE READING
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