Effect of recombinant soluble P-selectin glycoprotein ligand-1 on leukocyte-endothelium interaction in vivo. Role in rat traumatic shock.

@article{Scalia1999EffectOR,
  title={Effect of recombinant soluble P-selectin glycoprotein ligand-1 on leukocyte-endothelium interaction in vivo. Role in rat traumatic shock.},
  author={Rosario G Scalia and Richard D Hayward and Valerie E. Armstead and Alexander G. Minchenko and Allan M. Lefer},
  journal={Circulation research},
  year={1999},
  volume={84 1},
  pages={93-102}
}
-Traumatic shock induces profound pathophysiological alterations and initiates inflammatory reactions in many tissues, thus resulting in acute multiple organ damage (eg, intestine, pancreas, and liver). In the rat, Noble-Collip drum trauma increases P-selectin expression on the vascular endothelium as a result of loss of endothelium-derived NO. Here we postulated that blockade of the earliest steps in leukocyte adhesion (ie, leukocyte rolling) via administration of a recombinant soluble form of… CONTINUE READING

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