Effect of reaction-step-size noise on the switching dynamics of stochastic populations.

@article{Beer2016EffectOR,
  title={Effect of reaction-step-size noise on the switching dynamics of stochastic populations.},
  author={Shay Be'er and Metar Heller-Algazi and Michael Assaf},
  journal={Physical review. E},
  year={2016},
  volume={93 5},
  pages={
          052117
        }
}
In genetic circuits, when the messenger RNA lifetime is short compared to the cell cycle, proteins are produced in geometrically distributed bursts, which greatly affects the cellular switching dynamics between different metastable phenotypic states. Motivated by this scenario, we study a general problem of switching or escape in stochastic populations, where influx of particles occurs in groups or bursts, sampled from an arbitrary distribution. The fact that the step size of the influx… CONTINUE READING
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SHOWING 1-10 OF 37 REFERENCES

46] doi:10.1038/nature

  • 46] doi:10.1038/nature
  • 2015

Phys. Rev. E

S Be 'er, M Assaf, B Meerson
  • Phys. Rev. E
  • 2015

Genetics

M J Wittmann, W Gabriel, D Metzler
  • Genetics
  • 2014

Phys. Biol

T Earnest, E Roberts, M Assaf, K Dahmen, Z Luthey-Schulten
  • Phys. Biol
  • 2013

Phys. Rev. E

B Meerson, O Ovaskainen
  • Phys. Rev. E
  • 2013

Phys. Rev. Lett

M Assaf, E Roberts, Z Luthey-Schulten, N Goldenfeld
  • Phys. Rev. Lett
  • 2013

Cell Annu. Rev. Biophys

G Balázsi, A Van Oudenaarden, J J Collins
  • Cell Annu. Rev. Biophys
  • 2011

Phys. Rev. Lett

M Assaf, E Roberts, Z Luthey-Schulten
  • Phys. Rev. Lett
  • 2011

Science

D M Suter, N Molina, +3 authors F Naef
  • Science
  • 2011

J. Stat. Mech

M Assaf, B Meerson, P V Sasorov
  • J. Stat. Mech
  • 2010