Corpus ID: 7595900

Effect of 1,6-dihydro-2[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidineca rboxyli c acid on ethanol-induced microvascular injury in rats.

@article{Ishizuka1996EffectO1,
  title={Effect of 1,6-dihydro-2[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidineca rboxyli c acid on ethanol-induced microvascular injury in rats.},
  author={Y. Ishizuka and T. Kamisaki and H. Okamoto and M. Kawashima and M. Sato},
  journal={Arzneimittel-Forschung},
  year={1996},
  volume={46 8},
  pages={
          779-83
        }
}
  • Y. Ishizuka, T. Kamisaki, +2 authors M. Sato
  • Published 1996
  • Chemistry, Medicine
  • Arzneimittel-Forschung
  • To disclose the cytoprotective mechanism of 1,6-dihydro-2[2-(2-methyoxypropoxy)anilino]-6-oxo-5-pyrimidinecarb oxylic acid (CAS 98772-05-5, MAR-99), the effect of this compound on the microvascular injury in gastric mucosa induced by 99.5% ethanol in rats was studied. In this experiment, it was found that the elevation of vascular permeability observed at the early state of ethanol-induced gastric mucosal injury was closely correlated with the combined action of histamine and slow reacting… CONTINUE READING

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