Effect of rasagiline as adjunct therapy to levodopa on severity of OFF in Parkinson's disease.

@article{Stocchi2011EffectOR,
  title={Effect of rasagiline as adjunct therapy to levodopa on severity of OFF in Parkinson's disease.},
  author={Fabrizio Stocchi and Jos{\'e} Martin Rabey},
  journal={European journal of neurology},
  year={2011},
  volume={18 12},
  pages={1373-8}
}
BACKGROUND The LARGO study demonstrated that rasagiline 1 mg/day as adjunct to levodopa significantly reduces OFF time to the same magnitude as adjunct entacapone. This substudy of LARGO aimed to assess the effect of rasagiline and entacapone on the motor symptoms of PD during the practically defined OFF state. METHODS LARGO was a randomized, double-blind, multicenter trial that assessed the efficacy and safety of rasagiline (1 mg/day), entacapone (200 mg with each levodopa dose), and placebo… CONTINUE READING

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