Effect of rapamycin alone and in combination with antiangiogenesis therapy in an orthotopic model of human pancreatic cancer.

Abstract

PURPOSE The overall 5-year survival of patients with pancreatic cancer remains <5%. Novel therapeutic strategies are needed. We examined the effect of rapamycin, alone and in combination with antiangiogenesis therapy, on pancreatic cancer in vivo. EXPERIMENTAL DESIGN Human pancreatic cancer AsPC-1 cells were orthotopically injected into severe combined… (More)

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